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2018-2021

Eleventh round (2018) – supported studies

Mr. J. Kuiper, PhD Shooting the Messenger
Targeting ERAPs to combat Uveitis
Mrs. Prof. J.H. De Boer, PhD
Multifocal electroretinogram abnormalities in inflammatory macular edema
Mr. Prof. G.P.M. Luyten, PhD
BAP1 predisposition syndrome in familial uveal melanoma
Mrs E. Kiliç, PhD, MD
Spliceosome inhibitors as a therapeutic option for patients with a somatic SF3B1 mutation?
Mr. H.A. Freitas Alves
PILOT – A preclinical vision testing street for rodents
Mr. C.J.F. Boon, MD, PhD, FEBOphth
Stress, steroids, and the eye: unravelling the pathogenesis of central serous chorioretinopathy
Mr G. Melles, PhD, MD
Long-term evaluation of clinical outcome and complications after Bowman layer transplantation for progressive advanced keratoconus
Mrs. J. Ossewaarde-van Norel, PhD and mr. R. van Leeuwen, PhD Determinants and consequences of Bruch’s Membrane calcification in Pseudoxanthoma Elasticum
Mr. S. van der Stigchel, PhD
PILOT – Eye hear you: Improving auditory perception in blind individuals through the deployment of eye-movements
Mrs S. Roosing, PhD
PILOT – A long-read whole genome sequencing approach to unravel the genetic cause in inherited retinal dystrophies
Mrs. S. Micheal, PhD
PILOT – Identification of genetic causes of congenital cataract using sequencing technologies
Mr. T.T.J.M. Berendschot, PhD
Multispectral imaging for improved glaucoma detection and diagnosis
Mrs. R.M.A. van Nispen, PhD
PILOT – A new Patient Reported Outcome Measure (PROM) to assess anti-VEGF treatment in retinal exudative disease: the Dutch Impact of Visual Impairment profile Computer Adaptive Test (IVI-CAT). tissue screening and harvesting
Mrs. Prof. A.I. den Hollander, PhD
Monitoring oxidative stress in patients with age-related macular degeneration
Mrs. S.M.R. Jonker, MD en Mr. C.J.F. Bertens, M.Sc., B.A.Sc.
Molecular background of endothelial cell loss in patients with phakic intraocular lenses: a tear and aqueous humour study
Mrs. Prof. M.J. Jager, PhD
Contribution of pigmentation to the development of intraocular melanoma
Mr. R.W.J. Collin, PhD
Splicing modulation therapy for recurrent ABCA4 mutations underlying Stargardt disease
Mr. Prof. R.M.M.A. Nuijts, PhD
Efficiency and underlying molecular mechanisms of anti-inflammation treatment in keratoconus patients
Mr. T.G.M.F. Gorgels, PhD
Glaucoma-on-a-chip: an in vitro model for glaucoma drug discovery and precision medicine
Mr. R.O. Schlingemann, Prof., PhD, MD and Mrs. I. Klaassen, PhD
Novel targets in tip cells for anti-angiogenesis in exudative AMD
Mr. W.D. Ramdas, MD, PhD and Mrs. A.A.H.J. Thiadens, MD, PhD Nutrigenomics of open-angle glaucoma in different ethnicities
Mrs. A.I. Iglesias, PhD
RNA-sequencing of myopia zebrafish models
Prof. R.M.M.A. Nuijts, PhD
Collagen cross-linking by near infrared illumination (NIR) of Bacteriochlorophyll derivatives for the treatment of infectious keratitis: safety, efficacy and mechanisms of action
Mrs. M.A. Meester-Smoor, PhD
Why is good cholesterol bad for AMD?
Mr. R.J. Lebbink, PhD
In vivo inactivation of HSV-1 by CRISPR/Cas9-mediated genome mutagenesis: a cure for herpes keratitis?
Mrs. Prof. C.C.W. Klaver, PhD
RetinaNL Reading Center
 

Twelfth round (2019) – supported studies

Mr. G. Melles, PhD,
Long-term clinical outcomes and graft survival after Descemet membrane endothelial keratoplasty (DMEK)
Mr. Prof. J.C. van Meurs, PhD
Towards better treatment of postoperative endophthalmitis
Mrs. Prof. J.H. De Boer, PhD
PILOT – A pilot study for therapeutic tuning of dendritic cells in uveitis
Prof. C.B. Hoyng, PhD & Mrs. Prof. A.I. den Hollander, PhD
Towards treatment of central areolar choroidal dystrophy
Mrs. E. Kiliç, PhD, MD
PILOT – Unravelling the multifactorial role of BAP1 mutations in UM metastasis
Mrs. R. Kalmann, PhD
Prediction of therapeutic effect of steroids and the risk of recurrence in patients with inflammatory orbital disease via a blood test
Mr. J. Wijnholds, PhD
Development of novel gene editing techniques for retinal disease
Mr. Prof. C.J.F. Boon, MD, PhD, FEBOphth & Mrs. M. Talib, MD
PILOT – CRB1-associated retinal dystrophies: towards gene therapy
Mr. W.D. Ramdas, MD, PhD
The way towards neuroprotective modalities against glaucoma
Mrs. S. Yzer, PhD
Caucasian high and pathologic myopia: a clinical, genetic and epidemiological study
Mr. J.D. van Buul, PhD
Endothelial integrity to the max: corneal repair
Mr. E. van Wijk, PhD & Mr. E. de Vrieze, PhD
Pre-clinical development of a minigene augmentation therapy for the future treatment of USH2C-associated retinitis pigmentosa
Mr. A. Garanto, PhD
Therapeutic genome editing for ABCA4-associated Stargardt disease
Mrs. A.A.H.J. Thiadens, PhD, MD
Getting ready for gene therapy: gene finding and clinical management of cone dystrophies
Mr. Prof. F.W. Cornelissen, PhD
GazeJoy: Assessment of Ophthalmic and Visual Functioning using an Enjoyable Test and Stereoscopic Gaze Recording
Mr. T.G.M.F. Gorgels, PhD
PILOT – Towards treatment of glaucoma by a diet that bolsters mitochondrial function
Mr. Prof. R.O. Schlingemann, Prof., PhD, MD and Mrs. I. Klaassen, PhD
Novel targets in tip cells for anti-angiogenesis in exudative AMD
Mr. Prof. A.D.A. Paridaens, MD, PhD
PILOT – Towards a minimally invasive yet sufficient and safe orbital decompression in thyroid eye disease: a pilot cadaver study to compare three different techniques
Mr. Prof. Ir. R. Roepman, PhD
Improved human induced pluripotent stem cell (hiPSC)-derived model systems to assess disease mechanisms and treatment of retinal ciliopathies

Thirteenth round (2020) – supported studies

Mr. J. Wijnholds, PhD
PILOT – Autophagy and endolysosomal system dysregulation in human iPSC-derived retinal organoids
Mr. L.J. van Rijn, PhD
Safe driving for glaucoma patients with compensatory eye movements
Mr. G. Melles, PhD, MD
Bowman layer onlay grafting: New technique to flatten the corneal curvature and reduce progression in advanced keratoconus
Mr. J. Kuiper, PhD
Shooting the Messenger – Targeting ERAPs to combat Uveitis
Mrs. V. Koopman-Kalinina Ayuso, PhD
Systemic microcirculation and vascular impairment biomarkers in children with uveïtis
Mr. W.D. Ramdas, PhD, MD
Understanding glaucoma and discovery of biomarkers from the microbiome
Mr. K. Faridpooya, drs.
Robot-assisted cannulation of the central retinal vein and infusion of recombinant tissue plasminogen activator for the treatment of central retinal vein occlusion
Mr. Prof. M. Kamermans, PhD
Is infantile nystagmus in albinism and other retinal diseases also caused by oscillating cells in the retina?
Mr. E. van Wijk, PhD & Mr. E. de Vrieze, PhD
Recognition and understanding of sleeping problems associated with retinitis pigmentosa
Mr. Prof. F.P.M. Cremers, PhD
High-throughput sequence analysis of maculopathy probands employing smMIPs for all reported inherited and multifactorial maculopathy-associated genes and risk factors
Mrs. S. Yzer, PhD
PILOT – Posterior staphyloma and axial length progression over time: pilot study towards a randomized controlled trial.
Mr. P.E. Wagstaff, Mres
Functional and therapeutic assessment of the FOXC1/ATOH7 pathway in glaucoma using retinal organoids
Mrs. A. Leonte, drs.
Identifying individuals with glaucoma at risk for neurodegeneration in the brain by combining quantitative genetics and MRI
Mrs. J. Ossewaarde-van Norel, PhD, MD
Multimodal imaging in central multifocal choroiditis
Mr. J.W.M. Beenakker, PhD
MReye: MR-based treatment planning and follow-up for proton therapy of Uveal Melanoma
Mrs. I. Klaassen, PhD
Development of a zebrafish model for the pathological breakdown of the bloodretinal barrier
Mr. Prof. R.O. Schlingemann, PhD, MD and Mrs. I. Klaassen, PhD
Variations in genetic profile as predictors of treatment response in macular edema
Mrs. Prof. C.C.W. Klaver, PhD
High dose versus low dose atropine for myopia control: the Myopia Atropine Dose (MAD) trial
Mr. Prof. Ir. R. Roepman, PhD
Scrutinizing calmodulin-associated protein complex assembly in the photoreceptor connecting cilium towards therapeutic modulation of inherited retinal degeneration

Fourteenth round (2021) – supported studies

Mrs. E. E. Emri, PhD
3D printing of biosynthetic stem cell-derived retinal organoid tissue for modeling and therapeutic targeting of age-related macular degeneration and related disorders
Mr. Prof. C.J.F. Boon, MD, PhD
The final steps to gene therapy: defining clinical endpoints and test-retest reliability in patients with CBR1-associated retinal dystrophies
Mr. J.J.W. Kuiper, PhD
Vitamine D3 to repaire cDC2 subset balance in non-infectious uveitis
Mrs. A.A.H.J. Thiadens, PhD
A global glaucoma study on genetic variants, morphology and environmental risk factors in different ethnicities
Mr. J. Wijnholds, PhD
Generic drugs preventing blindness due to loss of USH2A function
Mr. Prof. M. Kamermans, PhD
Is infantile nystagmus in albinism and other retinal diseases also caused by oscillating cells in the retina?
Mrs. Prof. A. Moll, PhD
Cognitive functioning and quality of life in survivors of retinoblastoma, their siblings and children: the role of cancer treatment and repeated anesthesia
Mrs. S. Yzer, PhD
Choroidal neovascularization secondary to central serous chorioretinopathy: a clinical predicament
Mr. Prof. L.P.W.J. van den Heuvel, Mrs. Prof. A. I. den Hollander, PhD and Mrs. J. Gloerich, PhD
Role of factor H related proteins in the pathogenesis of age-related macular degeneration
Mrs. J. Ossewaarde-van Norel, PhD, MD
Genetic Risk factors in Central Multifocal Choroiditis
Mrs. Prof. H. van Bokhoven, PhD
Correction of hereditary variants in eye disorders
Mrs. I. Klaassen, PhD
PILOT-Aqueous humor biomarkers as potential predictors of treatment efficacy in patients with proliferative diabetic retinopathy
Mr. Prof. R.M.M.A. Nuijts, PhD
PILOT-Optimization of patient flow after cataract surgery in the COVID-19 era: AI-driven teleconversation will replace doctor consultation
Mr. T.G.M.F. Gorgels. PhD
Generation and purification of human retinal ganglion cells for glaucoma disease modelling
Mrs. Y.T.E. Lechanteur, PhD, MD
Molecular and clinical biomarkers for second eye progression: a prospective cohort study
Mrs. Prof. C.C.W. Klaver, PhD
EyeNED platform for smart diagnostics of eye diseases
Mr. Prof. Ir. R. Roepman, PhD
Scrutinizing actin-driven outer segment assembly in retinal organoids towards therapeutic reassembly in inherited retinal degeneration