2018-2022

Eleventh round (2018) – supported studies

Mr. J. Kuiper, PhD
Shooting the Messenger -Targeting ERAPs to combat Uveitis

Mrs. Prof. J.H. De Boer, PhD

Multifocal electroretinogram abnormalities in inflammatory macular edema

Mr. Prof. G.P.M. Luyten, PhD

BAP1 predisposition syndrome in familial uveal melanoma

Mrs E. Kiliç, PhD, MD

Spliceosome inhibitors as a therapeutic option for patients with a somatic SF3B1 mutation?

Mr. H.A. Freitas Alves

PILOT – A preclinical vision testing street for rodents

Mr. C.J.F. Boon, MD, PhD, FEBOphth

Stress, steroids, and the eye: unravelling the pathogenesis of central serous chorioretinopathy

Mr G. Melles, PhD, MD

Long-term evaluation of clinical outcome and complications after Bowman layer transplantation for progressive advanced keratoconus

Mrs. J. Ossewaarde-van Norel, PhD and mr. R. van Leeuwen, PhD Determinants and consequences of Bruch’s Membrane calcification in Pseudoxanthoma Elasticum

Mr. S. van der Stigchel, PhD

PILOT – Eye hear you: Improving auditory perception in blind individuals through the deployment of eye-movements

Mrs S. Roosing, PhD

PILOT – A long-read whole genome sequencing approach to unravel the genetic cause in inherited retinal dystrophies

Mrs. S. Micheal, PhD

PILOT – Identification of genetic causes of congenital cataract using sequencing technologies

Mr. T.T.J.M. Berendschot, PhD

Multispectral imaging for improved glaucoma detection and diagnosis

Mrs. R.M.A. van Nispen, PhD

PILOT – A new Patient Reported Outcome Measure (PROM) to assess anti-VEGF treatment in retinal exudative disease: the Dutch Impact of Visual Impairment profile Computer Adaptive Test (IVI-CAT). tissue screening and harvesting

Mrs. Prof. A.I. den Hollander, PhD

Monitoring oxidative stress in patients with age-related macular degeneration

Mrs. S.M.R. Jonker, MD en Mr. C.J.F. Bertens, M.Sc., B.A.Sc.

Molecular background of endothelial cell loss in patients with phakic intraocular lenses: a tear and aqueous humour study

Mrs. Prof. M.J. Jager, PhD

Contribution of pigmentation to the development of intraocular melanoma

Mr. R.W.J. Collin, PhD

Splicing modulation therapy for recurrent ABCA4 mutations underlying Stargardt disease

Mr. Prof. R.M.M.A. Nuijts, PhD

Efficiency and underlying molecular mechanisms of anti-inflammation treatment in keratoconus patients

Mr. T.G.M.F. Gorgels, PhD

Glaucoma-on-a-chip: an in vitro model for glaucoma drug discovery and precision medicine

Mr. R.O. Schlingemann, Prof., PhD, MD and Mrs. I. Klaassen, PhD

Novel targets in tip cells for anti-angiogenesis in exudative AMD

Mr. W.D. Ramdas, MD, PhD and Mrs. A.A.H.J. Thiadens, MD, PhD Nutrigenomics of open-angle glaucoma in different ethnicities

Mrs. A.I. Iglesias, PhD

RNA-sequencing of myopia zebrafish models

Prof. R.M.M.A. Nuijts, PhD

Collagen cross-linking by near infrared illumination (NIR) of Bacteriochlorophyll derivatives for the treatment of infectious keratitis: safety, efficacy and mechanisms of action

Mrs. M.A. Meester-Smoor, PhD

Why is good cholesterol bad for AMD?

Mr. R.J. Lebbink, PhD

In vivo inactivation of HSV-1 by CRISPR/Cas9-mediated genome mutagenesis: a cure for herpes keratitis?

Mrs. Prof. C.C.W. Klaver, PhD

RetinaNL Reading Center

Twelfth round (2019) – supported studies

Mr. G. Melles, PhD,
Long-term clinical outcomes and graft survival after Descemet membrane endothelial keratoplasty (DMEK)
Mr. Prof. J.C. van Meurs, PhD
Towards better treatment of postoperative endophthalmitis
Mrs. Prof. J.H. De Boer, PhD
PILOT – A pilot study for therapeutic tuning of dendritic cells in uveitis
Prof. C.B. Hoyng, PhD & Mrs. Prof. A.I. den Hollander, PhD
Towards treatment of central areolar choroidal dystrophy
Mrs. E. Kiliç, PhD, MD
PILOT – Unravelling the multifactorial role of BAP1 mutations in UM metastasis
Mrs. R. Kalmann, PhD
Prediction of therapeutic effect of steroids and the risk of recurrence in patients with inflammatory orbital disease via a blood test
Mr. J. Wijnholds, PhD
Development of novel gene editing techniques for retinal disease
Mr. Prof. C.J.F. Boon, MD, PhD, FEBOphth & Mrs. M. Talib, MD
PILOT – CRB1-associated retinal dystrophies: towards gene therapy
Mr. W.D. Ramdas, MD, PhD
The way towards neuroprotective modalities against glaucoma
Mrs. S. Yzer, PhD
Caucasian high and pathologic myopia: a clinical, genetic and epidemiological study
Mr. J.D. van Buul, PhD
Endothelial integrity to the max: corneal repair
Mr. E. van Wijk, PhD & Mr. E. de Vrieze, PhD
Pre-clinical development of a minigene augmentation therapy for the future treatment of USH2C-associated retinitis pigmentosa
Mr. A. Garanto, PhD
Therapeutic genome editing for ABCA4-associated Stargardt disease
Mrs. A.A.H.J. Thiadens, PhD, MD
Getting ready for gene therapy: gene finding and clinical management of cone dystrophies
Mr. Prof. F.W. Cornelissen, PhD
GazeJoy: Assessment of Ophthalmic and Visual Functioning using an Enjoyable Test and Stereoscopic Gaze Recording
Mr. T.G.M.F. Gorgels, PhD
PILOT – Towards treatment of glaucoma by a diet that bolsters mitochondrial function
Mr. Prof. R.O. Schlingemann, Prof., PhD, MD and Mrs. I. Klaassen, PhD
Novel targets in tip cells for anti-angiogenesis in exudative AMD
Mr. Prof. A.D.A. Paridaens, MD, PhD
PILOT – Towards a minimally invasive yet sufficient and safe orbital decompression in thyroid eye disease: a pilot cadaver study to compare three different techniques
Mr. Prof. Ir. R. Roepman, PhD
Improved human induced pluripotent stem cell (hiPSC)-derived model systems to assess disease mechanisms and treatment of retinal ciliopathies

Thirteenth round (2020) – supported studies

Mr. J. Wijnholds, PhD
PILOT – Autophagy and endolysosomal system dysregulation in human iPSC-derived retinal organoids
Mr. L.J. van Rijn, PhD
Safe driving for glaucoma patients with compensatory eye movements
Mr. G. Melles, PhD, MD
Bowman layer onlay grafting: New technique to flatten the corneal curvature and reduce progression in advanced keratoconus
Mr. J. Kuiper, PhD
Shooting the Messenger – Targeting ERAPs to combat Uveitis
Mrs. V. Koopman-Kalinina Ayuso, PhD
Systemic microcirculation and vascular impairment biomarkers in children with uveïtis
Mr. W.D. Ramdas, PhD, MD
Understanding glaucoma and discovery of biomarkers from the microbiome
Mr. K. Faridpooya, drs.
Robot-assisted cannulation of the central retinal vein and infusion of recombinant tissue plasminogen activator for the treatment of central retinal vein occlusion
Mr. Prof. M. Kamermans, PhD
Is infantile nystagmus in albinism and other retinal diseases also caused by oscillating cells in the retina?
Mr. E. van Wijk, PhD & Mr. E. de Vrieze, PhD
Recognition and understanding of sleeping problems associated with retinitis pigmentosa
Mr. Prof. F.P.M. Cremers, PhD
High-throughput sequence analysis of maculopathy probands employing smMIPs for all reported inherited and multifactorial maculopathy-associated genes and risk factors
Mrs. S. Yzer, PhD
PILOT – Posterior staphyloma and axial length progression over time: pilot study towards a randomized controlled trial.
Mr. P.E. Wagstaff, Mres
Functional and therapeutic assessment of the FOXC1/ATOH7 pathway in glaucoma using retinal organoids
Mrs. A. Leonte, drs.
Identifying individuals with glaucoma at risk for neurodegeneration in the brain by combining quantitative genetics and MRI
Mrs. J. Ossewaarde-van Norel, PhD, MD
Multimodal imaging in central multifocal choroiditis
Mr. J.W.M. Beenakker, PhD
MReye: MR-based treatment planning and follow-up for proton therapy of Uveal Melanoma
Mrs. I. Klaassen, PhD
Development of a zebrafish model for the pathological breakdown of the bloodretinal barrier
Mr. Prof. R.O. Schlingemann, PhD, MD and Mrs. I. Klaassen, PhD
Variations in genetic profile as predictors of treatment response in macular edema
Mrs. Prof. C.C.W. Klaver, PhD
High dose versus low dose atropine for myopia control: the Myopia Atropine Dose (MAD) trial
Mr. Prof. Ir. R. Roepman, PhD
Scrutinizing calmodulin-associated protein complex assembly in the photoreceptor connecting cilium towards therapeutic modulation of inherited retinal degeneration

Fourteenth round (2021) – supported studies

Mrs. E. E. Emri, PhD
3D printing of biosynthetic stem cell-derived retinal organoid tissue for modeling and therapeutic targeting of age-related macular degeneration and related disorders
Mr. Prof. C.J.F. Boon, MD, PhD
The final steps to gene therapy: defining clinical endpoints and test-retest reliability in patients with CBR1-associated retinal dystrophies
Mr. J.J.W. Kuiper, PhD
Vitamine D3 to repaire cDC2 subset balance in non-infectious uveitis
Mrs. A.A.H.J. Thiadens, PhD
A global glaucoma study on genetic variants, morphology and environmental risk factors in different ethnicities
Mr. J. Wijnholds, PhD
Generic drugs preventing blindness due to loss of USH2A function
Mr. Prof. M. Kamermans, PhD
Is infantile nystagmus in albinism and other retinal diseases also caused by oscillating cells in the retina?
Mrs. Prof. A. Moll, PhD
Cognitive functioning and quality of life in survivors of retinoblastoma, their siblings and children: the role of cancer treatment and repeated anesthesia
Mrs. S. Yzer, PhD
Choroidal neovascularization secondary to central serous chorioretinopathy: a clinical predicament
Mr. Prof. L.P.W.J. van den Heuvel, Mrs. Prof. A. I. den Hollander, PhD and Mrs. J. Gloerich, PhD
Role of factor H related proteins in the pathogenesis of age-related macular degeneration
Mrs. J. Ossewaarde-van Norel, PhD, MD
Genetic Risk factors in Central Multifocal Choroiditis
Mrs. Prof. H. van Bokhoven, PhD
Correction of hereditary variants in eye disorders
Mrs. I. Klaassen, PhD
PILOT-Aqueous humor biomarkers as potential predictors of treatment efficacy in patients with proliferative diabetic retinopathy
Mr. Prof. R.M.M.A. Nuijts, PhD
PILOT-Optimization of patient flow after cataract surgery in the COVID-19 era: AI-driven teleconversation will replace doctor consultation
Mr. T.G.M.F. Gorgels. PhD
Generation and purification of human retinal ganglion cells for glaucoma disease modelling
Mrs. Y.T.E. Lechanteur, PhD, MD
Molecular and clinical biomarkers for second eye progression: a prospective cohort study
Mrs. Prof. C.C.W. Klaver, PhD
EyeNED platform for smart diagnostics of eye diseases
Mr. Prof. Ir. R. Roepman, PhD
Scrutinizing actin-driven outer segment assembly in retinal organoids towards therapeutic reassembly in inherited retinal degeneration

Fifteenth round (2022) – supported studies

Mr. M.M. Dickman, PhD
OPTIMISE: Optimized immunosuppression for corneal transplantation
Mr. E.H.C. van Dijk, PhD
PILOT - Polypoidal choroidal vasculopathy in Caucasians
Mrs. Prof. J.H. de Boer, PhD
The Infectious Exposome of Childhood Uveitis
Mr. T. Theelen, PhD
Composite progression endpoints for the treatment of Stargardt disease
Mrs. I. Vázquez-Domínguez, PhD
PILOT - Investigating exosome content as novel marker for retinal diseases
Mrs. F.N. Boonstra, PhD
Optimal optic nerve analysis in children with CVI
Mr. Prof. J. van Buul, PhD & Mrs. M. Dallinga, PhD
PILOT - Endothelial integrity to the max: corneal repair
Mr. T.G.M.F. Gorgels, PhD
PILOT - Glaucoma Progression and Systemic Complement Activation
Mr. A.R.G.G. Potvin, Drs & Mr. Prof. P. Saeed, PhD
Magnetic Resonance lmaging and Clinical evaluation of Dysthyroid Optie Neuropathy and moderate-to-severe Graves' Orbitopathy: an observational prospective cohort study
Mr. Prof. M. Kamermans
Analysis of the development of infantile nystagmus and the associated low visual acuity?
Mrs. M.A. Meester-Smoor, PhD
Understanding vascularization and lipids in age-related macular degeneration.
Mrs. V. Kocaba, PhD
PILOT - ROCK inhibitor therapy to prevent corneal graft failure
Mrs. S. Yzer, PhD
PILOT - Prednisolone eye drop in chronic central serous chorioretinopathy: a randomised clinical trial
Mrs. D.T. Hartong, PhD & Mr. S.W. van der Meeren
PILOT - Treating socket discharge and discomfort: randomized test of vitamin A ointment, low-dose steroids and artificial tears
Mr. J. Wijnholds, PhD
PILOT - Retina-on-a-chip technology as screening platforms of therapies for ABCA4, USH2A, CRB1 and RPGR
Mr. R. van Leeuwen, PhD, MSc & Mrs.A. Ossewaarde-van Norel, PhD
Imaging and immunology of the eye in Pseudoxanthoma Elasticum
Mrs. R. Kalmann, PhD
Orbital inflammation and orbital lymphoma; new diagnostic techniques
Mrs. R.M.H. Diederen, MD, PhD
PILOT - Biomarkers related to retinal angiogenesis in proliferative sickle cell retinopathy
Mrs. I. Klaassen, PhD & Mrs. P. Serrano Martinez, MSc
PILOT - Stem cell-derived organoid models to study mechanisms involved in AMD
Mr. J. Wijnholds, PhD
Regeneration of the injured human retina
Mr. R.O.B. de Keizer, MSc, MD
PILOT - Improved diagnostics for Graves’ orbitopathy in serum
Mr. Prof. R. Roepman, PhD
PILOT - Evaluation of therapeutic efficacy of calmodulin inhibitors to rescue connecting cilium defects in retinitis pigmentosa and Leber congenital amaurosis.